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There is a strong societal need to evaluate and understand the sustainability of biofuels, especially because of the significant increases in production mandated by many countries, including the United States. Sustainability will be a strong factor in the regulatory environment and investments in biofuels. Biomass feedstock production is an important contributor to environmental, social, and economic impacts from biofuels.

The water consumption and agrochemical use during biofuel production could adversely impact both availability and quality of a precious resource.

In this paper, we assess what is known or anticipated about environmental and sustainability factors associated with next-generation biofuels relative to the primary conventional biofuels (i.e., corn grain-based ethanol and soybean-based diesel) in the United States during feedstock production and conversion processes. Factors considered include greenhouse (GHG) emissions, air pollutant emissions, soil health and quality, water use and water quality, wastewater and solid waste streams, and biodiversity and land-use changes.

The location of ethanol plants is determined by infrastructure, product and input markets, fiscal attributes of local communities, and state and federal incentives. This empirical
analysis uses probit regression along with spatial clustering methods to analyze investment activity of ethanol plants at the county level for the lower U.S. 48 states from 2000 to 2007.
The availability of feedstock dominates the site selection decision. Other factors, such as access to navigable rivers or railroads, product markets, producer credit and excise tax

Ethanol production using corn grain has exploded in the Upper Midwest. This new demand for corn, and the new opportunities
for value-added processing and cattle production in rural communities, has created the best economic development
opportunity in the Corn Belt states in a generation or more. Ethanol demand has increased rapidly recently because of favorable
economics of ethanol vs. gasoline, and the need for a performance enhancer to replace MTBE (methyl tertiary-butyl ether)